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Horm Metab Res 1989; 21(1): 33-36
DOI: 10.1055/s-2007-1009143
Clinical

© Georg Thieme Verlag, Stuttgart · New York

Effects of Alpha-2 Adrenoreceptor Blockade by Yohimbine on the Hormonal Response to Hypoglycaemic Stress in Normal Man

R. C. Cuneo, J. H. Livesey, M. G. Nicholls, E. A. Espiner, R. A. Donald
  • Department of Endocrinology, The Princess Margaret Hospital, Christchurch, New Zealand
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Publication History

1987

1988

Publication Date:
14 March 2008 (online)

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Summary

In order to evaluate the effect of alpha-2 adrenoreceptor blockade on the ACTH response to insulin-induced hypoglycaemia, six normal men were studied with and without yohimbine (30 mg p.o.) premedication. Despite a similar hypoglycaemic stimulus and significant suppression of the growth hormone response (P < 0.05), no change was observed in basal or stimulated plasma ACTH, cortisol, arginine vasopressin (AVP) or prolactin responses following yohimbine. We conclude that alpha-2 adrenoreceptor blockade with yohimbine does not significantly affect the ACTH response to hypoglycaemia in man.

Key-Words

Alpha-2 Adrenoreceptors - ACTH - Yohimbine - Insulin-Hypoglycaemia - Growth Hormone

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