Endoscopy 1994; 26(2): 235-238
DOI: 10.1055/s-2007-1008950
© Georg Thieme Verlag KG Stuttgart · New York

The Stress Response to Laparoscopic Cholecystectomy: Investigation of Endocrine Parameters

U. Deuss1 , J. Dietrich2 , D. Kaulen1 , K. Frey1 , W. Spangenberger2 , B. Allolio1 , M. Matuszczak3 , H. Troidl2 , W. Winkelmann1
  • 1Department of Internal Medicine II, University of Cologne, Germany
  • 2Department of Surgery II, University of Cologne, Germany
  • 3Department of Anesthesiology, Cologne-Merheim Hospital, Cologne, Germany
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Publication History

Publication Date:
17 March 2008 (online)

Abstract

Laparoscopic cholecystectomy, as a typical example of minimal invasive surgery, is associated with low complication rates and minimal patient discomfort, and provides the same safety as conventional cholecystectomy. In the present prospective observational study, endocrine parameters as indicators for stress response were measured. We investigated 53 patients with laparoscopy cholecystectomy and 12 patients with conventional cholecystectomy. Blood samples were taken pre-, peri-, and postoperatively for measurement of ACTH, cortisol, prolactin, and growth hormone, General anesthesia followed as standardized protocol. The increase in all stress hormones die not differ between patients in the two groups, and was comparable with that reported in the literature and the findings of our own previous studies in patients undergoing conventional cholecystectomy and elective colon resection. We conclude that laparoscopic cholecystectomy is associated with a pronounced endocrine stress response that does not account for the observed difference in the peri- and postoperative complication rate or patient comfort.