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J Reconstr Microsurg 1993; 9(5): 341-346
DOI: 10.1055/s-2007-1006741
DOI: 10.1055/s-2007-1006741
ORIGINAL ARTICLE
© 1993 by Thieme Medical Publishers, Inc.
Sciatic Nerve Regeneration Across Gaps within Collagen Chambers: The Influence of Epidermal Growth Factor
Further Information
Publication History
Accepted for publication 1993
Publication Date:
08 March 2008 (online)
![](https://www.thieme-connect.de/media/jrm/199305/lookinside/thumbnails/10.1055-s-2007-1006741-1.jpg)
ABSTRACT
The effects of Epidermal Growth Factor (EGF) on axonal regeneration of a sectioned sciatic nerve within collagen tubes were investigated in 15 rats. Following baseline electrophysiologic assessment, bilateral 7-mm nerve gaps were created and repaired by interposition of collagen tubes, into which EGF (left side) or type I collagen (right side) was instilled. After 4 or 8 weeks, axonal regeneration, measured by electro-physiologic and histologic means, was identical for the EGF and control legs. The conclusion is that EGF does not influence nerve regeneration within a collagen chamber.