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J Reconstr Microsurg 1996; 12(8): 559-563
DOI: 10.1055/s-2007-1006630
ORIGINAL ARTICLE

© 1996 by Thieme Medical Publishers, Inc.

Is Axonal Sprouting Able to Traverse the Conjunctival Layers of the Peripheral Nerve? A Behavioral, Motor, and Sensory Study of End-To-Side Nerve Anastomosis

Jayme Augusto Bertelli, Adair Roberto Soares dos Santos, Joao Batista Calixto
  • Departments of Pharmacology and Surgery, Division of Operative Technique and Experimental Surgery, Federal University of Santa Catarina, Florianópolis, Brazil
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Publication History

Accepted for publication 1996

Publication Date:
08 March 2008 (online)

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Letters to the EditorJ Reconstr Microsurg 1997; 13(08): 593-594
DOI: 10.1055/s-2007-1006442

ABSTRACT

The repair of large peripheral nerve defects is not always possible, especially when the proximal stump is not available. In these cases, end-to-side nerve anastomosis has been proposed. In the present experiment, using the terminal branches of the rat brachial plexus, the authors studied behavioral responses after end-to-side nerve anastomoses using fibrin glue, 3 and 6 months after surgery. Rats were evaluated by results of a grasping test, a capsaicin test and a hot-plate test. The collected data demonstrated that there was no functional motor or sensory reinnervation after the end-to-side nerve anastomoses. The conjunctive layers of the peripheral nerve thus represented an effective barrier to reinnervation.

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