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Horm Metab Res 1990; 22(12): 622-626
DOI: 10.1055/s-2007-1004988
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© Georg Thieme Verlag, Stuttgart · New York

The Effect of L-Acetylcarnitine on Some Reproductive Functions in the Oligoasthenospermic Rat

S. Palmero1 , M. Leone2 , M. Prati1 , M. Costa2 , M. Messeni Leone3 , E. Fugassa1 , L. De Cecco2
  • 1Istituto di Fisiologia Generale, Università di Genova, Genova, Italy
  • 2Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Genova, Italy
  • 3Istituto di Istologia ed Embriologia Generale, Università di Genova, Genova, Italy
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1990

1990

Publikationsdatum:
14. März 2008 (online)

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Summary

The effect of L-acetylcarnitine (LAC) on some parameters of male reproductive function was studied on rats made Oligoasthenospermic with dibromochloropropane (DBCP). DBCP depresses sperm count and motility. After one injection of the drug, LAC induces a recovery of both sperm count and motility but after two injections it is ineffective. This effect is also shown visually by microscopic examination of seminiferous tubules. Among the enzymatic activities evaluated as biochemical markers of testicular function both lactate dehydrogenase and NADPH-cytochrome P 450-reductase increased significantly (P < 0.05) after treatment with LAC in normal rats. LAC also stimulates testosterone production. It is suggested that LAC may affect testicular function.

Key words

L-Acetylcarnitine - Reproductive Function - Oligoasthenospermia