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DOI: 10.1055/s-2007-1004988
© Georg Thieme Verlag, Stuttgart · New York
The Effect of L-Acetylcarnitine on Some Reproductive Functions in the Oligoasthenospermic Rat
Publication History
1990
1990
Publication Date:
14 March 2008 (online)
![](https://www.thieme-connect.de/media/hmr/199012/lookinside/thumbnails/10.1055-s-2007-1004988-1.jpg)
Summary
The effect of L-acetylcarnitine (LAC) on some parameters of male reproductive function was studied on rats made Oligoasthenospermic with dibromochloropropane (DBCP). DBCP depresses sperm count and motility. After one injection of the drug, LAC induces a recovery of both sperm count and motility but after two injections it is ineffective. This effect is also shown visually by microscopic examination of seminiferous tubules. Among the enzymatic activities evaluated as biochemical markers of testicular function both lactate dehydrogenase and NADPH-cytochrome P 450-reductase increased significantly (P < 0.05) after treatment with LAC in normal rats. LAC also stimulates testosterone production. It is suggested that LAC may affect testicular function.
Key words
L-Acetylcarnitine - Reproductive Function - Oligoasthenospermia