The Effect of L-Acetylcarnitine on Some Reproductive Functions in the Oligoasthenospermic Rat

S. Palmero; M. Leone; M. Prati; M. Costa; M. Messeni Leone; E. Fugassa; L. De Cecco

doi:10.1055/s-2007-1004988

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000025.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Horm Metab Res 1990; 22(12): 622-626
DOI: 10.1055/s-2007-1004988

Originals Basic

The Effect of L-Acetylcarnitine on Some Reproductive Functions in the Oligoasthenospermic Rat

S. Palmero¹ , M. Leone² , M. Prati¹ , M. Costa² , M. Messeni Leone³ , E. Fugassa¹ , L. De Cecco²

¹Istituto di Fisiologia Generale, Università di Genova, Genova, Italy
²Istituto di Clinica Ostetrica e Ginecologica, Università di Genova, Genova, Italy
³Istituto di Istologia ed Embriologia Generale, Università di Genova, Genova, Italy

Further Information

Publication History

1990

1990

Publication Date:
14 March 2008 (online)

Also available at

PDF Download Permissions and Reprints

Summary

The effect of L-acetylcarnitine (LAC) on some parameters of male reproductive function was studied on rats made Oligoasthenospermic with dibromochloropropane (DBCP). DBCP depresses sperm count and motility. After one injection of the drug, LAC induces a recovery of both sperm count and motility but after two injections it is ineffective. This effect is also shown visually by microscopic examination of seminiferous tubules. Among the enzymatic activities evaluated as biochemical markers of testicular function both lactate dehydrogenase and NADPH-cytochrome P 450-reductase increased significantly (P < 0.05) after treatment with LAC in normal rats. LAC also stimulates testosterone production. It is suggested that LAC may affect testicular function.

Key words

L-Acetylcarnitine - Reproductive Function - Oligoasthenospermia