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Horm Metab Res 1990; 22(8): 423-425
DOI: 10.1055/s-2007-1004938
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© Georg Thieme Verlag, Stuttgart · New York

Activity of Enzymes Involved in Norepinephrine Biosynthesis in the Brown Adipose Tissue of the Developing Rat.

Influence of HypothyroidismM. F. Blouquit, D. Gripois
  • Laboratoire d'Endocrinologie, Université Paris-Sud, Orsay, France
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Publication History

1989

1990

Publication Date:
14 March 2008 (online)

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Summary

The activities of tyrosine hydroxylase (TH) and dopamine-beta-hydroxylase (DBH) were measured in vitro in the brown adipose tissue (BAT) of control and hypothyroid developing rats. Neonatal hypothyroidism slows the development of TH activity, as manifest in lower BAT TH activity, relative to controls, up to 20 days. This effect is more pronounced when the onset of hypothyroidism is induced prenatally. No clear effect of hypothyroidism on DBH activity was evident.

Key words

Tyrosine Hydroxylase - Dopamine Beta Hydroxylase - Hypothyroidism - Brown Adipose Tissue - Developing Rat