Exp Clin Endocrinol Diabetes 2008; 116(2): 94-98
DOI: 10.1055/s-2007-1004589
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Octyl-Methoxycinnamate (OMC), an Ultraviolet (UV) Filter, Alters LHRH and Amino Acid Neurotransmitters Release from Hypothalamus of Immature Rats

B. Szwarcfarb 1 , S. Carbone 1 , R. Reynoso 1 , G. Bollero 1 , O. Ponzo 1 , J. Moguilevsky 2 , P. Scacchi 1
  • 1Facultad de Medicina, de Fisiología, Buenos Aires, Argentina
  • 2Universidad Favaloro, Buenos Aires, Argentina
Weitere Informationen

Publikationsverlauf

received 22.03.2007 first decision 04.05.2007

accepted 26.06.2007

Publikationsdatum:
19. Februar 2008 (online)

Abstract

OMC (octyl-methoxycinnamate), is an endocrine disruptor with estrogenic activity, which is used in sunscreen creams as a UV filter. We studied its “in vitro” effects on the hypothalamic release of LHRH as well as on the amino acid neurotransmitter system in immature rats of 15 (prepubertal) and 30 (peripubertal) days of age. OMC decreased the LH-RH release significantly in male and female rats of both age. In male rats OMC increased the release of GABA while in the female ones It diminished the excitatory amino acid aspartate (ASP) and Glutamate (GLU) without modifications in the hypothalamic GABA release. These results suggest that during sexual maturation the inhibitory effect of OMC on LH-RH release appears to be related to its action on the inhibitory and excitatory amino acid neurotransmitters in male and female rats.

References

  • 1 Den Hond D, Schoeters G. Endocrine disrupters and human puberty.  Int J Androl. 2006;  29 ((1)) 264-271
  • 2 Harry H, Hirsch B, Leonhardt Wuttke W. Amino acid neurotransmitter release in the preoptic area of rats during the positive feedback actions of estradiol on LH release.  Neuroendocrinology. 1992;  56 133-140
  • 3 Janjua NR, Mogensen B, Andersson AM, Petersen JH, Henriksen M, Skakkaek NE, Wulf HC. Systemic absorption of the sunscreems benzophenone-3, octyl-methoxycinnamate, and 3-(4-methyl-benzylidene) camphor after whole body topical application and reproductive hormone levels in humans.  J Invest Dermatol. 2004;  123 57-61
  • 4 Lu JP, Zheng LX, Cai DP. Study on the level of environmental endocrine disrupters in serum of precocious patients.  Zhonghua Yu Fang Yi Xue, ZaZhi. 2006;  40 ((2)) 88-92
  • 5 Moguilevsky JA, Wuttke W. Changes in the control of gonadotrophin secretion by neurotransmitters during sexual maturation in rats.  Exp Clin Endocrinol Diabetes. 2001;  109 ((4)) 188-195
  • 6 Moguilevsky JA, Wuttke W. Changes in the control of ganadotrophins secretion by neurotransmitters during sexual development in rats.  Exp Clin Endocrinol Diabetes. 2001;  109 189-197
  • 7 Moguilevsky JA, Carbone S, Szwarcfarb B, Rondina D, Scacchi P. New concepts in the neurotransmitter control of gonadotropin secretion during sexual development. In: Bergadá C, Moguilevsky JA (Ed): Frontiers in Endocrinology Serono Symposium. 1995 10: 199-213
  • 8 Ojeda SR, Urbanski HF. Puberty in the rat. In: Knobill E, Neill JD (Ed). The physiology of reproduction. Raven press, New York 1994 2: 363-409
  • 9 Rastogi SC. UV filters in sunscreen products-a survey.  Contact Dermatitis. 2002;  46 ((6)) 348-351
  • 10 Rice C, Birnbaum LS, Cogliano J, Mahaffey K, Needham L, Rogan W, Saal FS Von. Exposure assessment for endocrine disrupters: some considerations in the design of studies.  Environ Health Perspect. 2003;  111 1683-1690
  • 11 Schlumpf M, Cotton B, Conscience M, Haller V, Seinmnn B, Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens.  Environ Health Perspect. 2001;  109 239-244
  • 12 Schlumpf M, Schmid P, Durrer S, Conscience M, Maerkel K, Henseler M, Gruetter M, Herzog I, Reolon S, Ceccatelli R, Faass O, Stutz E, Jarry H, Wuttke W, Lichtensteiger W. Endocrine Activity and develpmental toxicity of cosmetic UV filters-an update.  Toxicology. 2004;  205 113-122
  • 13 Schneider S, Deckardt K, Hellwig J, Kuttler K, Mellert W, Schulte S, Ravenzwaay B von. Octyl-methoxycinnamate: two generation reproduction toxicity in Wistar rats by dietary administration.  Food Chem Toxicol. 2005;  43 ((7)) 1083-1092
  • 14 Seidlová-Wuttke D, Jarry H, Cristoffel J, Rimoldi G, Wuttke W. Comparison of effects of estradiol (E2) with those of actylmethoxicinnamate (OMC) and 4-methylbenzyllidene camphor (4-MBC)-2 filters of UV light-on several uterine, vaginal and bone parameters.  Toxicol Appl Pharmacol. 2006;  210 246-254
  • 15 Seidlová-Wuttke D, Christoffel J, Rimoldi G, Jarry H, Wuttke W. Comparison of effects of estradiol with those of octylmethoxycinnamate and 4-methylbenzylidene camphor on fat tissue, lipids and pituitary hormones.  Toxicol Appl Pharmacol. 2006;  214 ((1)) 1-7
  • 16 Sharada Karanth Wen H, Yu Claudio M. Mastronardi and Samuel M. MacCann. 17ß-Estradiol Stimulates Ascorbic Acid and LHRH Release from the Medial Basal Hypothalamus in Adult Male Rats.  Experimental Biology and Medicine. 2004;  229 926-934
  • 17 Szwarcfarb B, Carbone S, Stein M, Medina J, Moguilevsky J. Sexual differences in the efect of the GABAergic system on LH secretion and in the hypothalamic ontogenesis of GABA A receptors in prepubertal rats.  Brain Res. 1994;  646 ((2)) 351-355
  • 18 Tukey JW. Comparing individual means the analysis of variance.  Biometrics. 1994;  5 99-114

Correspondence

Dr. B. Szwarcfarb

Facultad de Medicina

de Fisiología

Paraguay 2155

Buenos Aires

1121ABG

Argentina

Telefon: +54/1159/50 95 00

eMail: bertaburijson@yahoo.com.ar