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Horm Metab Res 1992; 24(10): 455-457
DOI: 10.1055/s-2007-1003361
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Glucogenolytic and Hyperglycemic Effect of 33-49 C-Terminal Fragment of Pancreastatin in the Rat in Vivo

V. Sánchez-Margalet, J. R. Calvo, R. Goberna
  • Departamento de Bioquímica Médica y Biología Molecular, Facultad de Medicina, Universidad de Sevilla, Sevilla, Spain
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Publication History

1991

1992

Publication Date:
14 March 2008 (online)

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Summary

The effects of the 33-49 C-terminal fragment of pancreastatin on glycogen content, glycemia, insulinemia and glucagonemia were studied in the rat in vivo. It was found that after intramesenteric vein injection of the peptide, the glycogen content of liver decreased compared with control group injected with saline-1 <% BSA. Blood glucose levels were increased by the C-terminal fragment of pancreastatin. This study shows that the 33-49 C-terminal fragment of pancreatasin could play a role in glucose metabolism not mediated by insulin or glucagon.

Key words

Pancreastatin - Glycogen - Insulin - Glucagon - Glucose - Rat