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Horm Metab Res 1992; 24(5): 225-228
DOI: 10.1055/s-2007-1003298
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© Georg Thieme Verlag, Stuttgart · New York

Insulin, at Physiological Concentrations, Enhances the Polymorphonuclear Leukocyte Chemotactic Properties

F. Cavalot, G. Anfossi, I. Russo, E. Mularoni, P. Massucco, S. Burzacca, L. Mattiello, M. Trovati
  • Department of Clinical and Biological Sciences of the University of Torino, San Luigi Gonzaga Hospital, Orbassano, Torino, Italy
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Publication History

1991

1992

Publication Date:
14 March 2008 (online)

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Summary

We investigated the influence of insulin on human polymorphonuclear leukocyte (PMN) chemotaxis induced by mediators in a microchamber assay. Insulin increased, with a dose-response relationship, chemotaxis induced by formyl-methionyl-leucyl-phenylalanine, calcium ionophore and phorbol-miristyl acetate (p = 0.0057, p = 0.0001 and p = 0.0215, respectively). The hormone effect was present also at the physiological concentration of 40 μU/ml. Our data show that insulin affects PMN activity in normal subjects and therefore support the hypothesis that insulin deficiency may be responsible for the impaired PMN function observed in diabetic patients in poor metabolic control.

Key words

Insulin - Polymorphonuclear Leukocytes - fMLP - PMA - CalciumIonophore