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Synthesis 2008(2): 267-271
DOI: 10.1055/s-2007-1000859
DOI: 10.1055/s-2007-1000859
PAPER
© Georg Thieme Verlag Stuttgart · New York
Phosphomolybdic Acid: Mild and Efficient Catalyst for Acetylation of Alcohols, Phenols, and Amines under Solvent-Free Conditions
Further Information
Received
19 September 2007
Publication Date:
18 December 2007 (online)
Publication History
Publication Date:
18 December 2007 (online)
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Abstract
Phosphomolybdic acid (PMA) has been found to be a simple and efficient catalyst for the acetylation of alcohols, phenols, and amines. Acetylation reactions with acetic anhydride (1.0 equiv) proceed in excellent yield in the presence of a catalytic amount (0.2 mol%) of PMA at ambient temperature within a relatively short reaction time (<10 min). Structurally diverse alcohols, phenols, and amines undergo acetylation under solvent-free conditions.
Key words
acetylation - phosphomolybdic acid - alcohols - amines - green catalysis
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