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Horm Metab Res 1994; 26(1): 33-38
DOI: 10.1055/s-2007-1000768
Originals Clinical

© Georg Thieme Verlag, Stuttgart · New York

Reduction of Erythrocyte (Na+-K+)ATPase Activity in Type 2 (Non-Insulin-Dependent) Diabetic Patients with Microalbuminuria

M. Mimura, H. Makino, A. Kanatsuka, T. Asai, S. Yoshida
  • Second Department of Internal Medicine, Chiba University, School of Medicine, Chiba, Japan
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Publication History

1993

1993

Publication Date:
14 March 2008 (online)

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Summary

In order to elucidate the causal relationship between (Na+-K+)ATPase and diabetic nephropathy, we studied the erythrocyte (Na+-K+)ATPase activity in Type 2 diabetic patients, 20 with microalbuminuria and 27 without microalbuminuria and in 16 control subjects. (Na+-K+)ATPase activities in microalbuminuric patients (0.273 ± 0.012 μmol Pi/mg protein/h, mean ± SE) were significantly reduced compared with those without microalbuminuric patients (0.308 ± 0.011 μmol Pi/mg protein/h, p<0.05) and control subjects (0.330 ± 0.011 μmol Pi/mg protein/h, p<0.01). Microalbuminuric patients had higher systolic blood pressure (133 ± 3 vs 124 ± 3 mmHg, p<0.05) and greater frequency of parental hypertension (50% vs 19%, p < 0.05) than those without microalbumininuria. (Na+-K+)ATPase activities in diabetic patients with hypertension were significantly reduced compared with those in diabetic patients without hypertension. Moreover, (Na+-K+)ATPase activities in diabetic patients with parental hypertension were significantly reduced compared with those in patients without parental hypertension. There was no difference in erythrocyte Na+ content between with and without microalbuminuria or hypertension or parental hypertension in diabetic patients. Erythrocyte Na+ content was significantly negatively correlated with (Na+-K+)ATPase activity in control subjects (r = -0.619, p<0.05), but not in diabetic patients (r = -0.194). Plasma digitalis-like substances showed no correlation with (Na+-K+)ATPase activities in diabetic patients with microalbuminuria or hypertension or parental hypertension. We concluded that the reduction of erythrocyte (Na+-K+)ATPase activity may be related to a familial predisposition to arterial hypertension and may partly be responsible for the development of diabetic nephropathy in Type 2 diabetic patients.

Key words

Erythrocyte (Na+-K+)ATPase Activity - NIDDM - Microalbuminuria - Hypertension

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