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Planta Med 1987; 53(2): 201-206
DOI: 10.1055/s-2006-962672
DOI: 10.1055/s-2006-962672
Full Papers
© Georg Thieme Verlag Stuttgart · New York
In Vitro Amoebicidal Testing of Natural Products; Part 2. Alkaloids Related to Emetine
Further Information
Publication History
1986
Publication Date:
24 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/198702/lookinside/thumbnails/10.1055-s-2006-962672-1.jpg)
Abstract
A series of 18 alkaloids with structural similarities to emetine have been tested for their in vitro activity against Entamoeba histolytica (NIH 200) and guinea-pig ear keratinocytes. The alkaloids contain either two benzyltetrahydroisoquinoline, two tetrahydro-β-carboline, or mixed benzyltetrahydroisoquinoline/tetrahydro-β-carboline moieties and are of the emetine, tubulosine, and ochrolifuanine class of alkaloids. The results are discussed on the basis of structure-activity relationships.