Planta Med 1988; 54(6): 494-497
DOI: 10.1055/s-2006-962527
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© Georg Thieme Verlag Stuttgart · New York

Effects of 5,7,2′,5′-Tetraacetoxy-4-phenylcoumarin in Guinea Pig Tracheal Preparations

C. C. Araújo, G. Thomas, M. Q. Paulo
  • Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Cidade Universitária, 58.059 João Pessoa, Paraíba, Brazil.
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Publikationsverlauf

1988

Publikationsdatum:
24. Januar 2007 (online)

Abstract

5,7,2′,5′-Acetoxy-4-phenylcoumarin relaxed normal isolated guinea pig trachea and those contracted with small doses of carbachol. While β-adrenoceptors are not involved in the relaxant effect, inhibition of Ca2+-influx may be an important mechanism since the degree of relaxation is inversely proportional to the Ca2+ concentration in the bath and since the cumulative concentration-effect curves to Ca2+ and K+ are antagonized by the coumarin. The compound also inhibited leukotriene-mediated arachidonic acid-induced contraction of indomethacin-treated trachea, but was inactive in antagonising ovalbumin-induced contractions of sensitized trachea.