Planta Med 1988; 54(3): 204-206
DOI: 10.1055/s-2006-962404
Papers

© Georg Thieme Verlag Stuttgart · New York

On the Podophyllotoxins of Root Cultures of Linum flavum

J. Berlin, N. Bedorf, C. Mollenschott, V. Wray, F. Sasse, G. Höfle
  • GBF - Gesellschaft für Biotechnologische Forschung m.b.H., Mascheroder Weg 1, D-3300 Braunschweig, Federal Republic of Germany.
Further Information

Publication History

1987

Publication Date:
24 January 2007 (online)

Abstract

The cytotoxic activity of root cultures of Linum flavum is due to the accumulation of 5-methoxypodophyllotoxin-4-β-D-glucoside. Depending on the cell extraction procedure only the aglycon may be found, as there is evidently a specific β-glucosidase present in the cells. The aglycon exhibits a 250-500 times higher cytotoxic activity than the glucoside.