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Planta Med 1992; 58(6): 489-492
DOI: 10.1055/s-2006-961532
Papers

© Georg Thieme Verlag Stuttgart · New York

Effect of Gomisin A (TJN-101) on Liver Regeneration

Shoji Kubo1 , Yasufumi Ohkura2 , Yasuhiro Mizoguchi2 , Isao Matsui-Yuasa3 , Shuzo Otani3 , Seiji Morisawa3 , Hiroaki Kinoshita1 , Shigefumi Takeda4 , Masaki Aburada4 , Eikichi Hosoya4
  • 1Second Department of Surgery, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
  • 2Third Department of Internal Medicine, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
  • 3Department of Biochemistry, Osaka City University Medical School, 1-5-7, Asahi-machi, Abeno-ku, Osaka 545, Japan
  • 4Tsumura Research Institute for Pharmacology, 3586, Yoshiwara, Ami-machi, Inashiki-gunn, Ibaraki 300-11, Japan
Further Information

Publication History

1991

Publication Date:
05 January 2007 (online)

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Abstract

We studied the effect of TJN-101, a lignan component of Schisandra fruits (Schisandrae fructus), on liver regeneration after partial hepatectomy. TJN-101 was given orally to male Wistar rats 30 min before partial hepatectomy. The mitotic index and the level of DNA synthesis increased after partial hepatectomy and their increase was significantly enhanced by TJN-101. Ornithine decarboxylase (ODC) activity increased in the early stages of liver regeneration and it was also significantly enhanced by TJN-101. Besides, TJN-101 enhanced the increase in hepatic putrescine. These results suggest that TJN-101 stimulates liver regeneration after partial hepatectomy by enhancing ODC activity, which is an important biochemical event in the early stages of liver regeneration.

Key words

TJN-101 - Schisandra fruits (Schisandrae fructus) - liver regeneration - mitosis - polyamines - ornithine decarboxylase