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Planta Med 1990; 56(3): 259-263
DOI: 10.1055/s-2006-960951
Paper

© Georg Thieme Verlag Stuttgart · New York

Anti-Platelet Action of GU-7, A 3-Arylcoumarin Derivative, Purified from Glycyrrhizae Radix

Masato Tawata1 , Yoshiki Yoda1 , Kaoru Aida1 , Hideo Shindo1 , Hiroshi Sasaki2 , Masao Chin2 , Toshimasa Onaya1
  • 1The Third Department of Internal Medicine, University ofYamanashi Medical School, Tamaho, Yamanashi 409-38, Japan
  • 2Tsumura Laboratory, Ami-machi, Ibaragi 300-11, Japan
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

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Abstract

We have purified GU-7, a 3-arylcoumarin derivative, from glycyrrhizae radix, which is a crude drug of kampo herbal medicines. This was identified to be a new chemical compound and was found to have an anti-platelet action. GU-7 inhibited platelet aggregation, phosphorylation of 40K and 20K dalton proteins, inositol 1,4,5-trisphosphate production, intraplatelet calcium increase and phosphodiesterase activity in vitro. The data indicate that GU-7 inhibits platelet aggregation by increasing intraplatelet cAMP concentration. We have already reported the existence of aldose reductase inhibitors in some kampo medicines. In addition to the aldose reductase inhibiting action, anti-platelet action may also explain the mechanism by which kampo medicines are effective to diabetic neuropathy.

Key words

3-Arylcoumarin derivative - anti-platelet action - phosphodiesterase inhibitor - kampo medicines