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Planta Med 1999; 65(8): 765-766
DOI: 10.1055/s-2006-960863
Letters

© Georg Thieme Verlag Stuttgart · New York

Hemistepsins with Cytotoxic Activity from Hemisteptia lyrata

Dae Sik Jang, Min Suk Yang, Tae Joung Ha, Ki Hun Park
  • Department of Agricultural Chemistry, Gyeongsang National University, Chinju, Korea
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Publication History

1999

1999

Publication Date:
04 January 2007 (online)

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Abstract

Two sesquiterpene lactones were isolated from Hemisteptia lyrata Bunge (Compositae). Their structures were elucidated by spectroscopic methods as recently known hemistepsin and the new 6-O-(2-methylpropenoyl)-3-hydroxy-4(15),10(14),11(13)-guaiatrien-12,8-olide. The two hemistepsin derivatives were examined for their in vitro cytotoxic activity against human cell lines such as UACC 62, HCT 15, UO-31, PC-3 and A549. Growth inhibitory property was determined by in vitro treatment of the respective cell lines using the sulforhodamine B assay (SRB). Both compounds exhibited significant cytotoxic activity (IC50 < 4.3 µg/ml) on all five human cell lines tested.