Novel Experimental Model using Free Radical-Induced Emesis for Surveying Anti-Emetic Compounds from Natural Sources

Ye Yang; Kaoru Kinoshita; Kiyotaka Koyama; Kunio Takahashi; Takaaki Tai; Yoshiki Nunoura; Kazuo Watanabe

doi:10.1055/s-2006-960829

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Planta Med 1999; 65(6): 574-576
DOI: 10.1055/s-2006-960829

Letters

Novel Experimental Model using Free Radical-Induced Emesis for Surveying Anti-Emetic Compounds from Natural Sources

Ye Yang¹ , Kaoru Kinoshita¹ , Kiyotaka Koyama¹ , Kunio Takahashi¹ , Takaaki Tai² , Yoshiki Nunoura² , Kazuo Watanabe³

¹Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Japan
²Kotaro Pharmaceutical Co, Ltd., Japan
³Faculty of Pharmaceutical Sciences, Chiba University, Japan

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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

A novel experimental model of free radical-induced emesis for screening anti-emetic compounds from natural sources was established. 2,2′-Azobis(2-amidinopropane) dihydrochloride (AAPH) dissolved in liposome induced emesis in young chickens, and the emesis was prevented by antioxidants including N-(2-mercaptopropionyl)-glycine (MFG), α-tocopherol, and L-ascorbic acid. Tropiseton, a serotonin receptor antagonist, also prevented emesis induced by AAPH. Known anti-emetic drugs and anti-emetic principles from natural sources also showed significant retching inhibition in the experiment using this system.