Download PDF
Planta Med 1999; 65(4): 371-374
DOI: 10.1055/s-2006-960791
Letters

© Georg Thieme Verlag Stuttgart · New York

The Anti-Inflammatory Compounds of Polygonum bistorta: Isolation and Characterisation

Mahama Duwiejua1 , 3 , Isaac J. Zeitlin1 , Alexander I. Gray2 , Peter G. Waterman2
  • 1Department of Physiology & Pharmacology, University of Strathclyde, Strathclyde Institute for Biomedical Sciences, Glasgow, U.K.
  • 2Phytochemistry Research Labs, Department of Pharmaceutical Sciences, Royal College, University of Strathclyde, Glasgow, U.K.
  • 3Present Address: Department of Pharmacology, Faculty of Pharmacy, UST, Kumasi, Ghana, West Africa
Further Information

Publication History

1998

1999

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

A bioassay-guided technique has been used to isolate anti-inflammatory compounds from the dried rhizomes of Polygonum bistorta, for structural identification. Anti-inflammatory activity was detected using the carrageenan-induced rat paw oedema. Two compounds were isolated which significantly suppressed the inflammatory response. Spectral data from EIMS and NMR together with some physical characteristics revealed the identities of the two active compounds as 5-glutinen-3-one and friedelanol. The results indicate that these two compounds largely account for the anti-inflammatory actions of the rhizomes of P. bistorta.