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Planta Med 1999; 65(4): 365-366
DOI: 10.1055/s-2006-960788
DOI: 10.1055/s-2006-960788
Letters
© Georg Thieme Verlag Stuttgart · New York
Colony Stimulating Factor-Inducing Activity of Hesperidin
Weitere Informationen
Publikationsverlauf
1998
1998
Publikationsdatum:
04. Januar 2007 (online)
Abstract
To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.