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Planta Med 1999; 65(4): 365-366
DOI: 10.1055/s-2006-960788
Letters

© Georg Thieme Verlag Stuttgart · New York

Colony Stimulating Factor-Inducing Activity of Hesperidin

Kiichiro Kawaguchi1 , Seiichi Kikuchi1 , Kimika Takayanagi1 , Takafumi Yoshikawa1 , 2 , Yoshio Kumazawa1
  • 1Medicinal Plant Garden, School of Pharmaceutical Sciences, Kitasato University, Sagamihara, Kanagawa, Japan
  • 2Department of Pharmacognosy, School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

To evaluate immunomodulating activities of bioflavones, colony-stimulating factor (CSF)-inducing activity of two dihydroflavones, three flavones and three flavonols were tested. These samples were suspended in saline and injected intraperitoneally (i.p.) into mice at a dose of 1 mg 6 h before bleeding. All compounds carrying the glucosyl-rhamnose moiety showed potent activity. Among them, hesperidin exhibited the strongest activity. Serum CSF production in mice injected with 1 mg hesperidin reached a peak at 9 h later. The activity of hesperidin was dose-dependent at a range of 0.3 to 20 mg/mouse.