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Planta Med 1999; 65(3): 263-266
DOI: 10.1055/s-2006-960772
Letter

© Georg Thieme Verlag Stuttgart · New York

Inhibition of Human Tumor Growth by 2′-Hydroxy- and 2′-Benzoyl-oxycinnamaldehydes

Chang Woo Lee, Dong Ho Hong, Sang Bae Han, Se Hyung Park, Hyae Kyeong Kim, Byoung-Mog Kwon, Hwan Mook Kim
  • Korea Research Institute of Bioscience and Biotechnology (KRIBB), Yusong, Taejon, Korea
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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

2′-Hydroxycinnamaldehyde (HCA) was isolated from Cinnamomum cassia Blume (Lauraceae) and 2′-benzoyloxycinna-maldehyde (BCA) was prepared by the reaction of HCA and benzoyl chloride. HCA and BCA strongly inhibited in vitro growth of 29 kinds of human cancer cells and in vivo growth of SW-620 human tumor xenograft without the loss of body weight in nude mice. HCA prevented adherence of SW-620 cells to the culture surface but did not inhibit oncogenic K-Ras processing, implying its antitumor mechanisms at the cellular level.