Download PDF
Planta Med 1999; 65(1): 74-76
DOI: 10.1055/s-2006-960443
Letter

© Georg Thieme Verlag Stuttgart · New York

Acyl-CoA:Cholesterol Acyltransferase Inhibitory Activity of Lignans Isolated from Schizandra, Machilus and Magnolia Species

Byoung-Mog Kwon1 , Hyun-Ju Jung2 , Jung-Hee Lim3 , Youn-Soo Kim3 , Mi-Kyung Kim1 , Young-Kook Kim1 , Song-Hae Bok1 , Ki-Hwan Bae2 , Ihn-Rhan Lee3
  • 1Protein Regulator RU, Korea Research Institute of Bioscience & Biotechnology, KIST, P.O. Box 115 Yoosung, Taejon, Korea
  • 2Chungnam National University, College of Pharmacy, Taejon, Korea
  • 3Ewha Womans University, College of Pharmacy, Seoul, Korea
Further Information

Publication History

1998

1998

Publication Date:
04 January 2007 (online)

Also available at
  PDF Download  Permissions and Reprints

Abstract

Fifteen lignans were isolated from the fruits of Schizandra chinensis, the leaves of Machilus thunbergii, and the flower buds of Magnolia denudata. They were identified as gomisins, schizandrin, wuweizisu, schizantherin, licarins, and machilin, which inhibited rat liver ACAT with IC50 values of 25-200 µM. Comisin N is the most potent inhibitor with IC50 value of 25 µM in these lignans.