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DOI: 10.1055/s-2006-960203
© Georg Thieme Verlag Stuttgart · New York
A New Phloroglucinol Derivative from Hypericum calycinum with Antifungal and in vitro Antimalarial Activity1
1 Presented in part at the 37th Congress of the Society of Medicinal Plant Research, Braunschweig, FRG, 5-9th September, 1989; Decosterd, L. A., Stoeckli-Evans, H., Chapuis, J.-C, Sordat, B., Hostettmann, K. (1989) Planta Med. 55, 629-630Publikationsverlauf
1990
Publikationsdatum:
05. Januar 2007 (online)
Abstract
The new phloroglucinol derivative 1 has been isolated from the light petroleum ether extract of the aerial parts of Hypericum calycinum. Its structure has been established by means of 1H- and 13C-NMR spectroscopy and by nOe, MHQC, and HMBC experiments on its monomethyl ether derivative 3. Compound 1 was fungicidal against Cladosporium cucumerinum in a TLC bioassay. In addition, this new phloroglucinol derivative was also found to exert an interesting antimalarial activity in an in vitro test system.
Key words
Hypericum calycinum - Cladosporium cucumerinum - phloroglucinol derivative - antifungal activity - antimalarial activity - Plasmodium falciparum