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DOI: 10.1055/s-2006-960199
© Georg Thieme Verlag Stuttgart · New York
Anti-Allergic Effect of Bryonolic Acid from Luffa cylindrica Cell Suspension Cultures
Publication History
1990
Publication Date:
05 January 2007 (online)
Abstract
The anti-allergic activity of bryonolic acid (1) isolated from the cultured cells of Luffa cylindrica L. (Cucurbitaceae) was compared with that of glycyrrhetinic acid (2), the aglycone of gylcyrrhizin from licorice. Compound 1, when administered to rats intraperitoneally at a dose of 600 mg/kg, inhibited homologous passive cutaneous anaphylaxis more strongly than 2 at the same dose. Compound 1 also significantly inhibited delayed hypersensitivity in mice which could not be inhibited by 2. In contrast to 2, 1 showed not only little toxicity but no visible side effects on mice, without impairing the activity of the hepatic enzyme (4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase) involved in steroid catabolism.
Key words
Anti-allergic activity - bryonolic acid - 3β-hydroxy-D:C-friedoolean-8-en-29-oic acid - glycyrrhetinic acid - Luffa cylindrica - cell suspension culture