4-Hydroxy-2-cyclopentenone: An Anti-Pseudomonas and Cytotoxic Component from Passiflora tetrandra1

N. B. Perry; G. D. Albertson; J. W. Blunt; A. L. J. Cole; M. H. G. Munro; J. R. L. Walker

doi:10.1055/s-2006-960048

Planta Medica, Table of Contents

Planta Med 1991; 57(2): 129-131
DOI: 10.1055/s-2006-960048

Papers

4-Hydroxy-2-cyclopentenone: An Anti-Pseudomonas and Cytotoxic Component from Passiflora tetrandra ¹

N. B. Perry² , G. D. Albertson³ , J. W. Blunt² , A. L. J. Cole³ , M. H. G. Munro² , J. R. L. Walker³

²Department of Chemistry, University of Canterbury, Christchurch, New Zealand
³Department of Plant and Microbial Sciences, University of Canterbury, Christchurch, New Zealand

1 Antibiotic Compounds from New Zealand Plants; Part IV.

Abstract

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Abstract

4-Hydroxy-2-cyclopentenone is responsible for the anti-bacterial activity of an extract of leaves from Passiflora tetrandra with minimum inhibitory doses (MID) of ca. 10 µg/disk against Escherichia coli, Bacillus subtilis, and Pseudomonas aeruginosa. 4-Hydroxy-2-cyclopentenone is also cytotoxic to P388 murine leukemia cells (IC₅₀ of < 1 µg/ml).

Key words

Passiflora tetrandra - Passifloraceae - 4-hydroxy-2-cyclopentenone - anti-pseudomonad - cytotoxic

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4-Hydroxy-2-cyclopentenone: An Anti-Pseudomonas and Cytotoxic Component from Passiflora tetrandra 1

4-Hydroxy-2-cyclopentenone: An Anti-Pseudomonas and Cytotoxic Component from Passiflora tetrandra ¹