Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa1

Binduja Shukla; P. K. S. Visen; G. K. Patnaik; B. N. Dhawan

doi:10.1055/s-2006-960010

Planta Medica, Table of Contents

Planta Med 1991; 57(1): 29-33
DOI: 10.1055/s-2006-960010

Papers

Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa ¹

Binduja Shukla, P. K. S. Visen, G. K. Patnaik, B. N. Dhawan

ICMR Centre for Advanced Pharmacological Research on Selected Traditional Remedies, Central Drug Research Institute, Post Box No. 173, Lucknow-226001 (U.P.), India

1 CDRI Communication No. 4583

Abstract

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Abstract

Picroliv, the hepatoprotective principle of the plant Picrorhiza kurroa, showed a dose-dependent (1.5 - 12 mg/kg × 7) choleretic effect in conscious rats and anaesthetised guinea pigs. It also possessed a marked anticholestatic effect against paracetamol- and ethynylestradiol-induced cholestasis. It antagonised the changes in bile volume as well as the contents (bile salts and bile acids). Silymarin, a known hepatoprotective agent, was tested simultaneously for comparison. Picroliv was found to be a more potent choleretic and anticholestatic agent than silymarin.

Key words

Picrorhiza kurroa - Picroliv - hepatoprotective agents - choleretic activity - anticholestatic activity - silymarin

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Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa 1

Choleretic Effect of Picroliv, the Hepatoprotective Principle of Picrorhiza kurroa ¹