Planta Med 1991; 57(1): 20-24
DOI: 10.1055/s-2006-960008
Papers

© Georg Thieme Verlag Stuttgart · New York

Pharmacology of Casimiroa edulis; Part I. Blood Pressure and Heart Rate Effects in the Anesthetized Rat

Gil A. Magos, Horacio Vidrio
  • Department of Pharmacology, School of Medicine, National University of Mexico, Apartado Postal 70297, 04510 Mexico, D. F., Mexico
Further Information

Publication History

1989

Publication Date:
05 January 2007 (online)

Abstract

The effect of an alcoholic extract of seeds of Casimiroa edulis on blood pressure and heart rate was determined in rats anesthetized with pentobarbital and compared with that of histamine. The extract induced hypotension, accompanied at high doses by tachycardia. Hypotension after histamine was more transient and was not accompanied by changes in heart rate. Experiments with a variety of autonomic antagonists revealed that extract-induced hypotension was not mediated by histamine H2, muscarinic, or beta-adrenergic receptors, but involved an H1 mechanism. After H1 blockade, the depressor response was reversed to a pressor effect, mediated by alpha-adrenoceptor stimulation. The increase in heart rate was due in part to H1 and in part to beta-adrenergic receptor activation. It was suggested that imidazole derivatives could be responsible for the depressor effect observed. The pressor response could be caused by these or other components of the extract.