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Planta Med 1993; 59(4): 337-339
DOI: 10.1055/s-2006-959695
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© Georg Thieme Verlag Stuttgart · New York

Platelet Aggregation Induced by Calceolarioside A in vitro: Role of Platelet Intracellular Calcium

A. Capasso1 , A. Di Giannuario2 , S. Pieretti2 , M. Nicoletti3
  • 1Dipartimento di Farmacologia Sperimentale, Università degli Studi di Napoli Federico II, via Domenico Montesano 49, I-80131 Napoli, Italy
  • 2Istituto Superiore di Sanità, viale Regina Elena 299, I-00161 Roma, Italy
  • 3Dipartimento di Biologia Vegetale, Università “La Sapienza”, piazzale Aldo Moro 5, I-00185 Roma, Italy
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Publication History

1992

1992

Publication Date:
04 January 2007 (online)

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Abstract

The effect of Calceolarioside A, a phenyl-propanoid glycoside (PhG), isolated from Calceolaria hypericina, was studied on rabbit platelets in vitro. Calceolarioside A induced a dose-related aggregant effect on rabbit platelets. Indomethacin did not modify the Calceolarioside A-induced aggregant effect. Furthermore, no modification was exerted by phenoxy-benzamine, BW 577C, and WEB 2086 on the PhG aggregant effect. On the contrary, TMB-8, an intracellular calcium blocker, significantly reduced the PhG effect. The latter result suggests that Calceolarioside A aggregation may be partly related to a calcium-dependent mechanism.

Key words

Calceolaria hypericina - Calceolarioside A - phenylpropanoid glycosides - platelet aggregation