Bellidifolin: A Potent Hypoglycemic Agent in Streptozotocin (STZ)-Induced Diabetic Rats from Swertia japonica

Purusotam Basnet; Shigetoshi Kadota; Mineo Shimizu; Tsuneo Namba

doi:10.1055/s-2006-959560

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Planta Med 1994; 60(6): 507-511
DOI: 10.1055/s-2006-959560

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Bellidifolin: A Potent Hypoglycemic Agent in Streptozotocin (STZ)-Induced Diabetic Rats from Swertia japonica

Purusotam Basnet¹ , Shigetoshi Kadota¹ , Mineo Shimizu² , Tsuneo Namba¹

¹Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
²Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan

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Publication History

1994

1994

Publication Date:
05 January 2007 (online)

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Abstract

Hypoglycemic activity-guided fractionation led to the isolation of five known xanthones and two triterpenoids from the ethyl acetate soluble fraction of Swertia japonica and their identification was based on spectroscopic methods. One of the triterpenes, thysano-lactone, was first isolated from this plant. Among the xanthones, bellidifolin showed a potent and dose-dependent hypoglycemic activity in STZ-induced diabetic rats both in i.p. and p.o. administration. A comparative hypoglycemic activity of the other three xanthones together with bellidifolin was also studied.

Key words

Swertia japonica - Gentianaceae - xanthones - bellidifolin - hypoglycemic activity - STZ-induced diabetes