Planta Med 1994; 60(6): 507-511
DOI: 10.1055/s-2006-959560
Papers

© Georg Thieme Verlag Stuttgart · New York

Bellidifolin: A Potent Hypoglycemic Agent in Streptozotocin (STZ)-Induced Diabetic Rats from Swertia japonica

Purusotam Basnet1 , Shigetoshi Kadota1 , Mineo Shimizu2 , Tsuneo Namba1
  • 1Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
  • 2Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-01, Japan
Further Information

Publication History

1994

1994

Publication Date:
05 January 2007 (online)

Abstract

Hypoglycemic activity-guided fractionation led to the isolation of five known xanthones and two triterpenoids from the ethyl acetate soluble fraction of Swertia japonica and their identification was based on spectroscopic methods. One of the triterpenes, thysano-lactone, was first isolated from this plant. Among the xanthones, bellidifolin showed a potent and dose-dependent hypoglycemic activity in STZ-induced diabetic rats both in i.p. and p.o. administration. A comparative hypoglycemic activity of the other three xanthones together with bellidifolin was also studied.