Planta Med 1994; 60(2): 133-135
DOI: 10.1055/s-2006-959434
Papers

© Georg Thieme Verlag Stuttgart · New York

Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis

F. Bonte, M. Dumas, C. Chaudagne, A. Meybeck
  • LVMH Recherche, 50 rue de Seine, F-92703 Colombes, France
Weitere Informationen

Publikationsverlauf

1993

1993

Publikationsdatum:
04. Januar 2007 (online)

Abstract

Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar nioiery of the molecule does not seem to be necessary for this biological acthdty.