In Vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from Echinacea and Achillea Species

Barbara Müller-Jakic; Walter Breu; Andrea Pröbstle; Karl Redl; Harald Greger; Rudolf Bauer

doi:10.1055/s-2006-959404

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Planta Med 1994; 60(1): 37-40
DOI: 10.1055/s-2006-959404

Paper

In Vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from Echinacea and Achillea Species

Barbara Müller-Jakic¹ , Walter Breu¹ , Andrea Pröbstle¹ , Karl Redl¹ , Harald Greger² , Rudolf Bauer¹ ^, ³

¹Institut für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-80333 München, Federal Republic of Germany
²Botanisches Institut der Universität Wien, Abteilung für Vergleichende Phytochemie, Rennweg 14, A-1030 Wien, Austria
³Institut für Pharmazeutische Biologie der Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Federal Republic of Germany

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Publication History

1993

1993

Publication Date:
04 January 2007 (online)

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Abstract

Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.

Key words

Achillea species - Echinacea angustifolia - Anacyclus pyrethrum - Aaronsohnia pubescens - Compositae - unsaturated alkamides - cyclooxygenase inhibition - 5-lipoxygenase inhibition