Planta Med 1994; 60(1): 37-40
DOI: 10.1055/s-2006-959404
Paper

© Georg Thieme Verlag Stuttgart · New York

In Vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase by Alkamides from Echinacea and Achillea Species

Barbara Müller-Jakic1 , Walter Breu1 , Andrea Pröbstle1 , Karl Redl1 , Harald Greger2 , Rudolf Bauer1 , 3
  • 1Institut für Pharmazeutische Biologie der Universität München, Karlstraße 29, D-80333 München, Federal Republic of Germany
  • 2Botanisches Institut der Universität Wien, Abteilung für Vergleichende Phytochemie, Rennweg 14, A-1030 Wien, Austria
  • 3Institut für Pharmazeutische Biologie der Universität Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Federal Republic of Germany
Further Information

Publication History

1993

1993

Publication Date:
04 January 2007 (online)

Abstract

Polyunsaturated alkamides isolated from Achillea species, Echinacea angustifolia DC., Anacyclus pyrethrum (L.) Link, and Aaronsohnia pubescens (Desf.) Bremer & Humphries, (Compositae) were shown to possess inhibitory activity in in vitro cyclooxygenase (sheep seminal microsomes) and 5-lipoxygenase (porcine leukocytes) assays. Activity appeared to depend on the particular structure of the alkamides.