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Planta Med 1995; 61(4): 360-362
DOI: 10.1055/s-2006-958101
Letters

© Georg Thieme Verlag Stuttgart · New York

Antifungal Principles of Baccharis pedunculata

Lila Rahalison1 , Messod Benathan2 , Michel Monod2 , Edgar Frenk2 , Mahabir P. Gupta3 , Pablo N. Solis3 , Nicola Fuzzati1 , Kurt Hostettmann1
  • 1Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, B.E.P., CH-1015 Lausanne, Switzerland
  • 2Service de Dermatologie, Centre Hospitalier Universitaire Vaudois(CHUV), CH-1011 Lausanne, Switzerland
  • 3Research Center for Pharmacognostic Studies of Panamanian Flora(CIFLORPAN), Faculty of Pharmacy, University of Panama, Apartado postal 10767, Estafeta Universitaria, Panama
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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Four compounds including a flavone, an acetylenic lactone, a prenylated coumarin, and a 3-methyl ether flavone were isolated from the dichloromethane leaf extract of Baccharis pedunculata (Mill.) Cabr. (Asteraceae). The latter three compounds were identified to be responsible for the antifungal activity against some human pathogenic and phytopathogenic fungi. The most active compound, lachnophyllum lactone, an acetylenic lactone, showed a very high toxicity (LD50 2 µg/ml) against human keratinocytes.