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DOI: 10.1055/s-2006-958094
© Georg Thieme Verlag Stuttgart · New York
Inhibition of Lipid Peroxidation and Superoxide Generation by Diterpenoids from Rosmarinus officinalis
Publication History
1994
1994
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199504/lookinside/thumbnails/10.1055-s-2006-958094-1.jpg)
Abstract
Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and microsomal lipid peroxidation induced by NADH or NADPH oxidation were also completely inhibited by these diterpenes at the concentration of 3-30 µM. Furthermore, carnosic acid protected red cells against oxidative hemolysis. These phenolic diterpenes were shown to be effective to protect biological systems against oxidative stresses.
Key words
Rosmarinus officinalis - Labiatae - carnosic acid - carnosol - rosmanol - epirosmanol - lipid peroxidation - superoxide anion