Planta Med 1995; 61(4): 307-312
DOI: 10.1055/s-2006-958089
Papers

© Georg Thieme Verlag Stuttgart · New York

Potent Antiplatelet, Anti-Inflammatory and Antiallergic Isoflavanquinones from the Roots of Abrus precatorius

Sheng-Chu Kuo1 , 4 , Sheng-Chih Chen1 , Lin-Hui Chen1 , Jin-Bin Wu1 , Jih-Pyang Wang2 , Che-Ming Teng3
  • 1Graduate Institute of Pharmaceutical Chemistry, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, Republic of China
  • 2Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China
  • 3Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan, Republic of China
  • 4National Research Institute of Chinese Medicine, Taipei, Taiwan, Republic of China
Further Information

Publication History

1994

1994

Publication Date:
04 January 2007 (online)

Abstract

Five isoflavanquinones have been isolated from the roots of Abrus precatorius L. (Leguminosae). Three of them are new and designated as abruquinones D, E, and F. The pharmacological activities of the isoflavanquinones have been evaluated. The results indicated that abruquinones A, B, and D exhibited remarkable inhibitory effects on the platelet aggregation. The IC50 of abruquinones A and B for the inhibition of the platelet aggregation induced by arachidonic acid (AA) and collagen were less than 5 µg/ml, and of abruquinone D, was less than 10 µg/ml for that induced by AA. On the other hand, abruquinones A, B, D, and F showed strong anti-inflammatory and antiallergic effects. The IC50 of abruquinones A, B, D, and F for the inhibition of superoxide formation were less than 0.3 µg/ml, for the inhibition of the release of both β-glucuronidase and lysozyme from rat neutrophils and the release of both β-glucuronidase and histamine from mast cells were less than 1 µg/ml.