In Vitro Antimalarial Activity of Quassinoids from Eurycoma longifolia against Malaysian Chloroquine-Resistant Plasmodium falciparum Isolates

Hooi Hoon Ang; Kit Lam Chan; Joon Wah Mak

doi:10.1055/s-2006-958042

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Planta Med 1995; 61(2): 177-178
DOI: 10.1055/s-2006-958042

Letters

In Vitro Antimalarial Activity of Quassinoids from Eurycoma longifolia against Malaysian Chloroquine-Resistant Plasmodium falciparum Isolates

Hooi Hoon Ang¹ , Kit Lam Chan¹ , Joon Wah Mak²

¹School of Pharmaceutical Sciences, University of Science Malaysia, Minden, 11800, Penang, Malaysia
²Filaria and Malaria Division, Institute for Medical Research, Jalan Pahang, 50588, Kuala Lumpur, Malaysia

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1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Three quassinoids from the roots of Eurycoma longifolia Jack were evaluated for anti-malarial activity against nine Plasmodium falciparum isolates obtained from patients infected with chloroquine-resistant malaria. The results indicated that eurycomanol, eurycomanol 2-O-β-D-glucopyranoside, and 13β,18-dihydroeurycomanol possessed anti-malarial activity with IC₅₀ values of 1.231 - 4.899 µM, 0.389 - 3.498 µM, and 0.504 - 2.343 µM, respectively, compared with 0.323 - 0.774 µM for chloroquine.