Usnic Acid and Diffractaic Acid as Analgesic and Antipyretic Components of Usnea diffracta

Emi Okuyama; Kazuhiro Umeyama; Mikio Yamazaki; Yasuhiro Kinoshita; Yoshikazu Yamamoto

doi:10.1055/s-2006-958027

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Planta Med 1995; 61(2): 113-115
DOI: 10.1055/s-2006-958027

Papers

Usnic Acid and Diffractaic Acid as Analgesic and Antipyretic Components of Usnea diffracta

Emi Okuyama¹ , Kazuhiro Umeyama¹ , Mikio Yamazaki¹ , Yasuhiro Kinoshita² , Yoshikazu Yamamoto²

¹Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoicho, Inage-ku, Chiba 263, Japan
²Research Center, Nippon Paint Co., Ltd., 19-17 Ikedanaka-machi, Neyagawa-shi, Osaka 572, Japan

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Publication History

1994

1994

Publication Date:
04 January 2007 (online)

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Abstract

Diffractaic acid and usnic acid were identified as the analgesic and antipyretic components of a lichen, Usnea diffracta. Both compounds showed an analgesic effect by the acetic acid-induced writhing and tail-pressure methods in mice. Regarding the effect on normal body temperature and LPS-induced hyperthermia in mice, diffractaic acid showed a significant effect only on the former and usnic acid only on the latter.

Key words

Usnea diffracta - Usneaceae - diffractaic acid - usnic acid - analgesic effect - antipyretic effect - hypothermic effect