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DOI: 10.1055/s-2006-957969
© Georg Thieme Verlag Stuttgart · New York
Different Mechanisms involved in the Vasorelaxant Effect of Flavonoids Isolated from Satureja obovata
Publication History
1996
1996
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199606/lookinside/thumbnails/10.1055-s-2006-957969-1.jpg)
Abstract
The inhibitory effects of naringenin, eriodictyol, and luteolin (10-5 and 5 × 10-5M), previously isolated from Satureja obovata subsp. obovata var. valentina (Lamiaceae), on rat thoracic aorta were investigated. Flavonoids at the two concentrations assayed (10-5 and 5 × 10-5 M) showed different smooth muscle relaxant behaviour in the three phases involved in the noradrenaline (10-6 M)-induced contractions. The three flavonoids showed an inhibitory effect of the phasic component in order of potency: luteolin > eriodictyol > naringenin. Luteolin and eriodictyol inhibited both tonic-I and tonic-II phases associated to the inhibition of PKC and calcium influx, respectively, whereas naringenin only inhibited the tonic-I phase associated to inhibition of PKC.