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Planta Med 1996; 62(4): 359-360
DOI: 10.1055/s-2006-957904
Letters

© Georg Thieme Verlag Stuttgart · New York

Production of Methyl 3-Oxoartemisinate from Methyl Artemisinate by Suspension Cell Culture of Mentha piperita

Soo-Un Kim, Hyung-Jin Kwon
  • Department of Agricultural Chemistry and The Research Center for New Biomaterials in Agriculture, College of Agriculture and Life Sciences, Seoul National University, Suwon 441-744, Korea
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1995

1996

Publikationsdatum:
04. Januar 2007 (online)

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Abstract

Methyl artemisinate was fed to the suspension cell culture of Mentha piperita. The biotransformation product was isolated and identified as a novel compound, methyl 3-oxoartemisinate. The Mentha cells were apparently capable of extensively oxidizing at the allylic C-3 position, to give rise to an oxo group. The conversion of the fed methyl ester of the acid reached a maximum in 48 h with 5.5% conversion. The physicochemical data of the oxo compound are presented.