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DOI: 10.1055/s-2006-957835
© Georg Thieme Verlag Stuttgart · New York
Antiplatelet and Vasorelaxing Actions of Some Aporphinoids
Publication History
1995
1995
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199602/lookinside/thumbnails/10.1055-s-2006-957835-1.jpg)
Abstract
A series of aporphines and oxoaporphines was tested for antiplatelet and vasorelaxing actions. (+)-N-Methylactinodaphnine, (-)-norannuradhapurine HBr, xylopine, actinodaphnine, and N-methylnandigerine showed strong inhibition of adenosine 5′-diphosphate (ADP)-induced platelet aggregation. Boldine, (+)-N-methylactinodaphnine, (-)-norannuradhapurine HBr, xylopine, N-acetyllaurolitsine, N-methyllaurotetanine, actinodaphnine, N-methylnandigerine, O-methylbulbocapnine, and liriodenine showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. (+)-N-Methylactinodaphnine, fissoldine HClO4, (-)-norannuradhapurine HBr, xylopine, N-methyllaurotetanine, actinodaphnine, N-methylnandigerine, O-methylbulbocapnine, and liriodenine showed strong inhibition of collagen-induced platelet aggregation. (-)-Norannuradhapurine HBr, xylopine, N-methyllaurotetanine, and actinodaphnine showed strong inhibition of platelet-activating factor (PAF; 1 -O-alkyl-2-acetyl-sn-glycero-3-phosphocholine)-induced platelet aggregation. (+)-N-Methylactinodaphnine, laurotetanine, N-methylactinodaphnine N-oxide, oxoglaucine, boldine, and actinodaphnine showed vasorelaxing action in rat thoracic aorta. The results are discussed on the basis of structure-activity relationships.
Key words
Antiplatelet aggregation - vasorelaxing action - aporphines - oxoaporphines