Antifungal and Antibacterial Chalcones from Myrica serrata

Abstract

The dichloromethane extract of the leaves of Myrica serrata inhibits growth of Cladosporium cucumerinum, Bacillus subtilis, and Escherichia coli on TLC plates. Activity-guided fractionation led to the isolation of 2′,4′-dihydroxy-6′-methoxy-3′,5′-dimethyl-chalcone (1), 2′,4′-dihydroxy-6′-methoxy-5′-methyl-chalcone (aurentiacin A) (2), 2′,6′-dihydroxy-4′-methoxy-3′,5′-dimethyldihydrochalcone (3), 2′-hydroxy-4′,6′-dimethoxy-3′-methyldihydrochalcone (4), and 2′, 6′-dihydroxy-4′-methoxy-3′-methyldihydrochalcone (5). In addition, the flavanones demethoxymatteucinol (6) and cryptostrobin (7) were also identified.