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Planta Med 1997; 63(5): 471-472
DOI: 10.1055/s-2006-957739
Letters

© Georg Thieme Verlag Stuttgart · New York

6-Methoxy-N-methyl-1,2,3,4-tetrahydro-β-carboline from Evodiae Fructus

Li-Li Yu1 , Li-Kang Ho1 , Jyh-Fei Liao1 , Chieh-Fu Chen2
  • 1Department and Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan
  • 2National Research Institute of Chinese Medicine, Taipei, Taiwan
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Publication History

1996

1997

Publication Date:
04 January 2007 (online)

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Abstract

A receptor binding assay directed separation has led to the identification of a minor alkaloid 6-methoxy-N-methyl-1,2, 3,4-tetrahydro-β-carboline (1) from the Chinese herbal drug Evodiae Fructus [EF, the dried, unripe fruit of Evodia rutaecarpa Look. f. et Thomas (Rutaceae)]. The structure of compound 1 was elucidated by means of spectroscopic methods and a comparison with synthetic materials. Compound 1 interacted with 5-HT1A and 5-HT2 receptors with a moderate Ki value of 78 and 1.2 µM, respectively. Compound 1 is found in EF and the genus Evodiae for the first time.

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