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DOI: 10.1055/s-2006-957727
© Georg Thieme Verlag Stuttgart · New York
Antiviral Activity of Natural Sulphated Galactans on Herpes Virus Multiplication in Cell Culture
Publikationsverlauf
1996
1997
Publikationsdatum:
04. Januar 2007 (online)
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Abstract
A sulphated galactan (SG) with low molecular weight (app. 2800) was isolated from extracts of Cryptopleura ramosa, a red seaweed from the South American coasts. The compound was a selective inhibitor of HSV-1 and HSV-2 replication in Vero cells with 50% inhibitory concentrations (IC50) in the range 1.6-4.2 µg/ml and a 50% cytotoxic concentration (CC50) of 476 µg/ml. SG was also effective against HSV-1 in cells of neural origin such as murine astrocytes. The mode of action of SG could be ascribed to an inhibitory action on virus adsorption. Furthermore, SG did not inhibit the blood coagulation process at concentrations highly exceeding the IC50.
key words
Natural antiviral - herpes simplex virus - sulphated polysaccharide - Cryptopleura ramosa - Delesseriaceae - red seaweed