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Planta Med 1997; 63(1): 15-17
DOI: 10.1055/s-2006-957594
Papers
Pharmacology and Molecular Biology
© Georg Thieme Verlag Stuttgart · New York

Cytotoxicity and Immunosuppressive Activity of Withanolides from Discopodium penninervium

Solomon Habtemariam
  • Department of Physiology and Pharmacology, University of Strathclyde, Glasgow G1 1XW, U.K.
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Publication History

1996

1996

Publication Date:
04 January 2007 (online)

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Abstract

The cytotoxicity and immunosuppressive activities of jaborosalactone-L and three 16α-oxygenated withanolides from the leaves of Discopodium penninervium were studied. Jaborosalactone-L showed cytotoxicity only to the murine macrophage cell line, RAW 264.7, but the 16α-oxygenated withanolides exhibited cytotoxicity to both human (COR-L23 and ECV 304) and murine (L929 and RAW 264.7) carcinoma cell lines with IC50 values ranging from 1.2-150 µM. The non-toxic concentrations of these withanolides were also found to reduce the proliferative response of both inactive and E. coli lipopolysaccharide and concanavalin A activated rat spleen cells in vitro.

Key words

Discopodium penninervium - Solanaceae - withanolides - cytotoxicity - immunosuppressive activity