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DOI: 10.1055/s-2006-957513
© Georg Thieme Verlag Stuttgart · New York
A New Antioxidative 1,3-Benzodioxole from Melissa officinalis
Publikationsverlauf
1997
1998
Publikationsdatum:
01. Februar 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199806/lookinside/thumbnails/10.1055-s-2006-957513-1.jpg)
Abstract
Antioxidative compounds contained in the leaves of Melissa officinalis L. (lemon balm) were investigated. Six major compounds, protocatechuic acid (or 3,4-dihydroxybenzoic acid, 1), 2-(3′,4′-dihydroxyphenyl)-1,3-benzodioxole-5-aldehyde (2), caffeic acid (3), rosmarinic acid (4), caffeic acid methyl ester (5), and rosmarinic acid methyl ester (6) were isolated from the extract of the plant and the 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity was measured. Among them, compound 2 showed the most potent activity, about ten-fold that of ascorbic acid and of α-tocopherol. The compound had a characteristic 1,3-benzodioxole structure and was easily degraded into two molecules of protocatechualdehyde.
Key words
Melissa officinalis L. - Labiatae - antioxidative activity - 1,1-diphenyl-2-picrylhydrazyl (DPPH) - rosmarinic acid - 1,3-benzodioxole structure - protocatechualdehyde