Planta Med 1998; 64(5): 468-470
DOI: 10.1055/s-2006-957487
Letters

© Georg Thieme Verlag Stuttgart · New York

Corosolic Acid Isolated from the Fruit of Crataegus pinnatifida var. psilosa is a Protein Kinase C Inhibitor as well as a Cytotoxic Agent

Kyung-Seop Ahn1 , Moon Sun Hahm1 , Eun Jin Park1 , Hyeong-Kyu Lee1 , Ik-Hwan Kim2
  • 1Korea Research Institute of Bioscience and Biotechnology, Taejon, Republic of Korea
  • 2Graduate School of Biotechnology, Korea University, Seoul, Repulic of Korea
Further Information

Publication History

1997

1998

Publication Date:
04 January 2007 (online)

Abstract

Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay.