Corosolic Acid Isolated from the Fruit of Crataegus pinnatifida var. psilosa is a Protein Kinase C Inhibitor as well as a Cytotoxic Agent

Kyung-Seop Ahn; Moon Sun Hahm; Eun Jin Park; Hyeong-Kyu Lee; Ik-Hwan Kim

doi:10.1055/s-2006-957487

Planta Medica, Table of Contents

Planta Med 1998; 64(5): 468-470
DOI: 10.1055/s-2006-957487

Letters

Corosolic Acid Isolated from the Fruit of Crataegus pinnatifida var. psilosa is a Protein Kinase C Inhibitor as well as a Cytotoxic Agent

Kyung-Seop Ahn¹ , Moon Sun Hahm¹ , Eun Jin Park¹ , Hyeong-Kyu Lee¹ , Ik-Hwan Kim²

¹Korea Research Institute of Bioscience and Biotechnology, Taejon, Republic of Korea
²Graduate School of Biotechnology, Korea University, Seoul, Repulic of Korea

Abstract

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Abstract

Corosolic acid isolated from the fruit of Crataegus pinnatifida var. psilosa was tested for anticancer activity. Corosolic acid displayed about the same potent cytotoxic activity as ursolic acid against several human cancer cell lines. In addition, the compound displayed antagonistic activity against the phorbol ester-induced morphological modification of K-562 leukemic cells, indicating the suppression of protein kinase C (PKC) activity by the cytotoxic compound. The compound showed PKC inhibition with dose-dependent pattern in an in vitro PKC assay.

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