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DOI: 10.1055/s-2006-957468
© Georg Thieme Verlag Stuttgart · New York
Antiphlogistic and Antipyretic Activity of Peucedanum ostruthium
Publication History
1997
1998
Publication Date:
04 January 2007 (online)
![](https://www.thieme-connect.de/media/plantamedica/199805/lookinside/thumbnails/10.1055-s-2006-957468-1.jpg)
Abstract
Extracts from the roots of Peucedanum ostruthium (L.) Koch were investigated for their antiphlogistic and antipyretic effects as well as for their influence on arachidonic acid metabolism. On carrageenan-induced rat paw edema, oral administration of 10% ethanolic extracts led to a marked inhibition of the edema. By means of bioassay-oriented fractionation of extract, 6-(3-carboxybut-2-enyl)-7-hydroxycoumarin proved to be the most important anti-inflammatory principle of the plant. 30 µg/kg of this compound inhibited the formation of edema to an extent of 50%. On the perfused rabbit ear and on polymorphonuclear leukocytes the extract and the active compound have been characterized as dual inhibitors of cyclooxygenase and 5-lipoxygenase activities. Moreover, an antipyretic effect of i.p. administered extract and compound were evaluated in rats with comparable hyperthermia after s.c. injection of brewer's yeast.
Key words
Peucedanum ostruthium - Apiaceae - roots - antiphlogistic and antipyretic effect - 6-(3-carboxybut-2-enyl)-7-hydroxycoumarin.