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Planta Med 1998; 64(4): 319-323
DOI: 10.1055/s-2006-957442
Papers
Pharmacology
© Georg Thieme Verlag Stuttgart · New York

Niaziminin, a Thiocarbamate from the Leaves of Moringa oleifera, Holds a Strict Structural Requirement for Inhibition of Tumor-Promoter-Induced Epstein-Barr Virus Activation

Akira Murakami1 , Yumi Kitazono2 , Suratwadee Jiwajinda3 , Koichi Koshimizu1 , Hajime Ohigashi2
  • 1Department of Biotechnological Science, Faculty of Biology-Oriented Science and Technology, Japan
  • 2Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
  • 3Environmental Science Unit, Central Laboratory and Greenhouse Complex, Kasetsart University, Thailand
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Publication History

1997

1997

Publication Date:
04 January 2007 (online)

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Abstract

Three known thiocarbamate (TC)- and isothiocyanate (ITC)-related compounds have been isolated from the leaves of Moringa oleifera, a traditional herb in southeast Asia, as inhibitors of tumor promoter teleocidin B-4-induced Epstein-Barr virus (EBV) activation in Raji cells. Interestingly, only niaziminin among 10 TCs including 8 synthetic ones showed considerable inhibition against EBV activation. The structure-activity relationships indicated that the presence of an acetoxy group at the 4′-position of niaziminin is important and indispensable for inhibition. On the other hand, among the ITC-related compounds, naturally occurring 4-[(4′-O-acetyl-α-L-rhamnosyloxy)benzyl]ITC and commercially available allyl- and benzyl-ITC significantly inhibited activation, suggesting that the isothiocyano group is a critical structural factor for activity.

Key words

Anti-tumor promoter - niaziminin - Epstein-Barr virus - thiocarbamate - isothiocyanate - Moringa oleifera - Moringaceae